Although you suspect aspergillus, which of the following cannot be ruled out. Pseudallescheria boydii releases metallopeptidases capable of. Pseudallescheria boydii infections treated with ketoconazole. The majority of infections are mycetomas, the remainder. Pseudallescheria boydii is a fungal organism known to affect immunocompromised patients. Scedosporium apiospermum sca is the anamorph or asexual state of the ascomycete pseudallescheria boydii. Its commonest clinical presentation in the usa is as mycetoma, a chronic limited subcutaneous infection in immunocompetent individuals engendered by minor. Pseudallescheria boydii anamorph scedosporium apiospermum. Dec 01, 2001 read pseudallescheria boydii knee arthritis in a young immunocompetent adult two years after a compound patellar fracture, joint bone spine on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Marys hospital, seoul, republic of korea 2 department of neurosurgery, college of medicine, the catholic university of korea. Therapy with ciprofloxacin, acyclovir, and amphotericin b was prophylactically initiated when chemotherapy was begun. The structures of the new compounds were elucidated on the basis of the spectroscopic analysis, and the absolute configurations including the sulfur stereogenic center. Their structures were elucidated by comprehensive analysis of the nmr. Pseudallescheria boydii anamorph scedosporium apiospermum infection in solid organ transplant recipients in a.
Pdf the study compared the growth of pseudallescheria boydii isolates from sewage sludge and from clinical sources. Pseudallescheria boydii infection of the brain surgical. Pseudallescheria boydii infection after bone marrow. Pseudallescheria boydii infection of the central nervous. Pseudallescheria boydii infectionstreated with ketoconazole. Vertebral osteomyelitis secondary to pseudallescheria boydii. Eightyfour isolates belonging to eight species that constitute the pseudallescheria boydii complex were tested against 11 antifungal agents by. Species diagnosis using histomorphology and polymerase chain reaction revealed p. Three new compounds 911 were isolated together with eight known analogues from the fungus pseudallescheria boydii associated with the south china sea soft coral sinularia sandensis. Pseudoalleschia boydii is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine.
Osteoclastogenesis regulation metabolites from the coral. Cell wall modifications during conidial maturation of the. Scedosporium apiospermum is a ubiquitous saprophytic fungus commonly found in soil, manure, decaying vegetation, and polluted water. The taxonomy of this genus has been subject to change on the basis of sequence data. Morphologically, the organism has relatively narrow, regularly septated, hyaline hyphae, with acute angle branching. Pseudallescheria boydii is a species of fungus classified in the ascomycota. This organism, a soil and water natural inhabitant, is known to cause madura foot and in severe cases, invasive infection of various organs central nervous, cardiovascular, respiratory systems. Glucan of pseudallescheria boydii is involved in fungal. Molecular phylogeny of the pseudallescheria boydii species.
Pseudallescheria boydii petriellidium boydii infection of. Pseudallescheria boydii anamorph scedosporium apiospermum is a ubiquitous ascomycetous fungus that causes a wide array of human infections that can affect practically all the organs of the body. An emerging fatal cause of fungal abscess and ventriculitis after neardrowning mingi lee 1, jingyu choi 1, byungchul son 2 1 department of neurosurgery, college of medicine, the catholic university of korea, seoul st. Invasive infection caused by pseudallescheria boydii in an. Pseudallescheriasis definition of pseudallescheriasis by. Tracking the emerging human pathogen pseudallescheria. Despite voriconazole therapy and surgical resection, the patients died.
Pseudallescheria boydii infection after bone marrow transplantation conrad h. It is a cosmopolitan saprophyte that can be isolated from moist soil, polluted water, and sewage. Read pseudallescheria boydii knee arthritis in a young immunocompetent adult two years after a compound patellar fracture, joint bone spine on deepdyve, the largest online rental service for scholarly research with thousands. Pseudallescheria boydii in an immunocompromised host. Pdf a study of the growth of pseudallescheria boydii isolates from. Scedosporium apiospermum is the anamorph, or asexual state, of the cosmopolitan fungus pseudallescheria boydii, with both sharing the same risk factors for infection, clinical spectrum, and. Pseudallescheria boydii is a fungal pathogen that causes disease in immunocompromised patients. Herein, we describe the isolation and structural characterization of an. The pseudallescheria boydii complex, comprising environmental pathogens with scedosporium anamorphs, has recently been subdivided into five main. Pseudallescheria boydii petriellidium boydii infection. A 56 year old, right handed africanamerican man with past history of left knee osteoarthritis, remote intravenous drug use, remote alcoholism, and seropositivity for hepatitis c was admitted to a local hospital for fatigue, chest pain.
Sca is a ubiquitous fungus present in soil, sewage, and polluted waters. Novel isobenzofuranone derivatives from marine fungus pseudallescheria boydii associated with starfish acanthaster planci by wenjian lan 1,2, wei liu 1,3, wanling liang 1, zeng xu 4, xiu le 1, jun xu 1, chikeung lam 4, depo yang 1,2, houjin li 4, and laiyou wang 3. Scedosporiumpseudallescheria infections request pdf. It is commonly believed that infection by this fungus occurs through. Bensch westerdijk fungal biodiversity institute, uppsalalaan 8, utrecht, the netherlands botanische staatssammlung munchen, menzinger stra. To better determine the best treatment of this lesion, the authors evaluated a case p. It is associated with some forms of eumycetoma, maduromycosis and pseudallescheriasis. Factors predisposing to central nervous system infection with this fungus include immunosuppression and near drowning. Fungal culture of specimens of the mycotic plaque yielded pseudallescheria boydii. Pseudallescheria boydii anamorph scedosporium apiospermum is the species responsible for human scedosporiosis, a fungal infection with a high mortality rate and which is difficult to treat. Progress in extending the life expectancy of cystic fibrosis cf patients remains jeopardized by the increasing incidence of fungal respiratory infections.
Thirty and 60 days after treatment was initiated, the nasal cavity was found to be free of infection. We have performed a morphological and molecular study involving numerous strains of clinical or environmental. Ceramide monohexosides cmhs were purified from lipidic extracts of this fungus, showing that, as described for several other species, p. Pseudallescheria boydii is a rare cause of central nervous system infection characteristically presenting as a neutrophilic meningitis or multiple brain abscesses. Polyketides from the littoral plant associated fungus. Recent advances in molecular taxonomy have advanced the understanding of the genus scedosporium and have demonstrated a wider range of species than heretofore recognized.
These infections have been known for a long time, but in recent years, a marked increase in severe invasive infections has been noticed, mainly in. However, the molecular nature of fungal ligands responsible for this activation is largely unknown. Pseudallescheria boydii an overview sciencedirect topics. Clinical observations and data obtained from experimental models indicate the essential role of innate immunity in resistance against. Pdf sca is a ubiquitous filamentous fungus capable of causing invasive disease. The clinical spectrum of pseudallescheriasis is wide. Scedosporium apiospermum pseudallescheria boydii endocarditis. Pulmonary fungal ball of pseudallescheria boydii identified. Media in category pseudallescheria boydii the following 2 files are in this category, out of 2 total. Because pseudallescheria boydii vertebral osteomyelitis is rare and frequently resistant to available antifungal agents, the proper treatment of this lesion has not been defined.
The horse was treated with 2% miconazole intranasally, sodium iodide i. On examination, a loud systolic murmur was present. Scedosporium apiospermum and its sexual form pseudallescheria boydii, a soil and waterborne fungus, has been incriminated as a common causative agent in this setting. Concerning liver relt n 44, we identified 6 patients 14% with filamentous fungal. Jan 17, 2011 pseudallescheria boydiiscedosporium apiospermum fungus pseudallescheria boydii sexual state teliomorph scedosporium apiospermum asexual state the names above refer to the same fungus exhibiting different reproductive states. Identification of pseudallescheria and scedosporium species by. Pseudallescheria boydii has long been known to cause white grain mycetoma in immunocompetent humans, but it has recently emerged as an opportunistic pathogen of humans, causing potentially fatal invasive infections in immunocompromised individuals and evacuees of natural disasters, such as tsunamis and hurricanes. Pseudallescheria boydii sensu lato is a complex of species involved in severe human infections.
Invasive fungal sinusitis caused by pseudallescheria. The thoracoabdominal aorta was affected in one patient, and cerebral vessels were affected in the other. Scedosporium apiospermum is the anamorph, or asexual state, of the cosmopolitan fungus pseudallescheria boydii, with both sharing the same risk factors for. Pseudallescheriasis is a fungal infection caused by pseudallescheria species, such as pseudallescheria boydii. We have performed a morphological and molecular study involving numerous strains. Pdf pseudallescheria boydii infection of the nasal.
Brain abscesses due to pseudallescheria boydiiassociated with primary nonhodgkins lymphoma of the central nervous system. Clinical observations and data obtained from experimental models indicate the essential role of innate immunity in. Its commonest clinical presentation in the usa is as mycetoma, a chronic limited subcutaneous infection in immunocompetent individuals engendered by minor trauma, and is characterised by grain. Case presentation a 10yearold white male was struck beneath the right eye by a. Pseudallescheria boydii is a recognized cause of mycetoma, a chronic fungal disease that usually affects the extremities. Angioinvasive complications of scedosporium infections are rare. The nasomaxillary opening appeared to be larger than normal. Report of a case a 63yearold man with acute myelogenous leukemia was admitted for induction chemotherapy with cytosine arabinoside and daunorubicin.
The structures of the new compounds were elucidated on the basis of the spectroscopic analysis, and the absolute configurations including the sulfur stereogenic center of a sulfoxide moiety were determined by. Central nervous system cns infection is an uncommon but serious complication of neardrowning. Pseudallescheria boydii pneumonia in an immunocompetent host. Pseudallescheria boydii is a saprophytic fungus widespread in soil and polluted water and has recently emerged as an agent of localized as well as disseminated infections in both immunocompromised and immunocompetent hosts. Pseudallescheria boydii is a saprophytic fungus frequently isolated from agricultural and industrial soil and from polluted water 1. We report two cases of mycotic aneurysm, following apparent localized infection, due to scedosporium apiospermum and pseudallescheria boydii. Four previously unreported chemical entities, boydone a 1, boydone b 2, botryorhodine f 3, and botryorhodine g 4, along with five known compounds, fusidilactone a 5, r. If the address matches an existing account you will receive an email with instructions to reset your password. Scedosporium apiospermum, pseudallescheria boydii, central nervous system infections, brain abscess, cerebral infections, fungal meningitis. Characterization of glucosylceramides in pseudallescheria. Pseudallescheria boydii is a ubiquitously occurring fungus that rarely causes infection in immunocompetent hosts but is now being recognized as an important emerging opportunistic pathogen in immunocompromised patients. Pronunciation of pseudallescheria boydii with 1 audio pronunciation, 1 translation and more for pseudallescheria boydii.
Pseudallescheria boydii is an opportunistic filamentous fungus that causes. Colonies grow rapidly and have a cottony appearance on cornmeal agar. Pseudoalleschia boydii is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes. Case presentation a 10yearold white male was struck beneath the right eye by. Pseudallescheria boydii strains cbs 119458 ccf 3082, dh 16421 and cbs 116895 fmr 6694, ihem 21168, mymo 2005. Orbital apex syndrome secondary to a sphenoidal sinus mycetoma of pseudallescheria boydii has also been reported. Pdf pseudallescheria boydii infection of the nasal cavity. Scedosporium apiospermum, the anamorph of pseudallescheria boydii, was isolated from the. Sca is a ubiquitous fungus present in soil, sewage, and polluted waters 30. Disseminated pseudallescheria boydii infection successfully. Pseudallescheria boydii is an infectious fungal pathogen of humans 7, 16, 40, 58, 59.
Typically found in stagnant and polluted water, it has been implicated in the infection of immunocompromised and neardrowned pneumonia patients. Tracking the emerging human pathogen pseudallescheria boydii. Invasive fungal sinusitis caused by pseudallescheria boydii. Breakthrough scedosporium apiospermum pseudallescheria boydii. Pseudallescheria boydii definition of pseudallescheria. Pseudallescheria boydii infection of the central nervous system. Pulmonary fungal ball of pseudallescheria boydii identified by lsu rdna d2 region sequencing miyoung kim, mihee ahn, ji sang kang, hyun lee, seiick joo, sung sup park, euichong kim department of laboratory medicine, seoul national university hospital, seoul, korea we report a case of pulmonary fungal ball of pseu. Scedosporium apiospermum and scedosporium boydii formerly pseudallescheria boydii are now recognised as separate species and along with s.
Antifungal susceptibilities of the species of the pseudallescheria. Pseudallescheria boydii has long been known to cause white grain mycetoma in immunocompetent humans, but it has recently emerged as an. Pseudallescheria species and their anamorphs in the genus scedosporium classically are known as traumatically. The composition of the culture medium has great influence on the metabolite production of the marine fungus pseudallescheria boydii f441. The cellfree pbsglucose supernatant was submitted to sdspage and 12. Pseudallescheria boydii arthritis and osteomyelitis in a patient with cushings disease. Pseudallescheria boydii is an opportunistic fungus that can cause systemic infection mainly in immunocompromised patients that manifests as pulmonary, osteoarticular, ocular. Pseudallescheria boydii is an opportunistic fungus that can cause systemic infection mainly in immunocompromised patients that manifests as pulmonary, osteoarticular, ocular, vascular, cutaneous. Rapid identification of pseudallescheria and scedosporium strains. By adding amino acids to gpy culture medium, two new bisindole alkaloids, pseudboindoles a and b 1 and 2, together with 11 known indole alkaloids were isolated from the culture broth. The sexual state name pseudallescheria boydii takes priority over the asexual state name scedosporium apiospermum. Improvement of pretreatment abnormalities occurred in five patients, one of whom had concurrent arthrodesis of his infected knee.